结构式：

基本信息：

中文名称：甲氧基聚乙二醇硅烷(MPEG-Silane)

中文别名：甲氧基-PEG-硅烷

英文名称：MPEG-Silane

CAS：-

分子量：350、500、550、750、1K、2K、5K、10K、20K

纯度：95%以上

应用简介：

Ethoxyor methoxyl silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxylsilane. Pegylation can greatly suppress the non-specific binding of charged moleculesto the modified surfaces. And they have wide applications for medica device,biomems or biocompatible material development.

ReactionProcedures:

Generally,silane PEG is first dissolved in a mixture of ethanol/water solution, thenallow the solution  to contact with oxidized glass or silica surface for 30 minto 2 hours. Under this condition, silane PEG should bind to the materialcovalently.

MaterialsRequired:

Pegylationsolution: Ethanol/water (w/w, 95%/5%);

SilanePEG stock solution, 10~50 mg/mL in pegylation solution, prepare in fresh.

Washingsolution: Distilled water.

ReactionSteps:

1.Dissolve targeted materials in Pegylation buffer.

2. Addsilane PEG stock solution to the targeted conjugation materials with the finalconcentration keep at least 10 mg/mL. 10~50 molar excess of silane PEG neededfor optimal conjugation;

3.Allow mixture agitates at room temperature for 30 min at room temperature or 2hours at 4 -20℃.

4. Washout unreacted materials either by distilled water.

物理性质：

状态：液体或者固体，取决于分子量。

溶解性：溶于DMSO,DMF,DCM。

保持条件：-20℃长期保存，避光，干燥。

注意事项：取用一定要干燥，避免频繁的溶解和冻干。

技术指标：

纯度（PEG）：95%以上

取代率（SIL）：90%以上

分散系数（PDI）：小于等于1.05

分析：COA、GPC、NMR、MALDI-TOF

（接受特殊分子量的定制：350、550、500、750）